Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance |
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| Authors: | Takashi Sakurai Mariko Tsuchida Paul D. Lampe Masahiro Murakami |
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| Affiliation: | 1. Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA;2. Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan;3. Translational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA |
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| Abstract: | Cardiac remodeling resulting from impairment of myocardial integrity leads to heart failure, through still incompletely understood mechanisms. The fibroblast growth factor (FGF) system has been implicated in tissue maintenance, but its role in the adult heart is not well defined. We hypothesized that the FGF system plays a role in the maintenance of cardiac homeostasis, and the impairment of cardiomyocyte FGF signaling leads to pathological cardiac remodeling. |
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| Keywords: | FGF, fibroblast growth factor Cx43, connexin43 S, serine MOI, multiplicity of infection PFU, plaque forming units Ad, adenovirus WT, wild type NA, numerical aperture SD, standard deviation HA, hemagglutinin DAPI, 4&prime ,6-diamidino-2-phenylindole |
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