The tripartite motif family identifies cell compartments |
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| Authors: | Reymond A Meroni G Fantozzi A Merla G Cairo S Luzi L Riganelli D Zanaria E Messali S Cainarca S Guffanti A Minucci S Pelicci P G Ballabio A |
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| Institution: | Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy. |
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| Abstract: | A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments. |
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