多巴胺在缺血性脑损伤中作用机制的研究进展

多巴胺是哺乳动物脑内重要的儿茶酚胺灰神经递质,但在某些病理条件下可引起神经毒性作用。近年来研究表明,ＤＡ在缺血性脑损伤中有重要作用。缺血时ＤＡ的酶促氧化和自身氧化导致自由基的产生被认为是ＤＡ神经毒性的主要原因,但这一观点尚需进一步探讨。

Mechanisms underlying dopaminergic neurotoxicity in ischemic cerebral damage

Dopamine(DA) is a neurotransmitter, but it also serves as a neurotoxin under certain pathological conditions. Accumulating evidences indicate that DA plays an important role in ischemic cerebral damage. The mechanism by which DA exacerbates the neuronal damage remains unclear. Many mechanisms have been proposed to explain the DA neurotoxicity. One possibility is that DA leads to the formation of free radicals which are cytotoxic. Another possibility is that direct dopamine receptor stimulation may mediate dopaminergic neurotoxicity. It is also possible that DA modulates excitotoxicity of excitatory amino acid.