An integrated genetic and physical map of the 650-kb region containing the congenital polycystic kidney (cpk) locus on mouse chromosome 12. |
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| Authors: | M Mrug W J Green S DasGupta D R Beier W Lu P D'Eustachio L M Guay-Woodford |
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| Affiliation: | Division of Nephrology, University of Alabama at Birmingham, Birmingham AL 35294-0007, USA. |
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| Abstract: | Mice homozygous for the congenital polycystic kidney (cpk) mutation develop a rapidly progressive form of polycystic kidney disease. We report an integrated genetic and physical map of the 650-kb region containing the cpk locus and the exclusion of Rrm2 and Idb2 as candidate cpk genes. Our study establishes the requisite foundation for positional cloning of the cpk gene. |
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