The baboon model (Papio hamadryas) of fetal loss: maternal weight,age, reproductive history and pregnancy outcome |
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| Authors: | Natalia E Schlabritz‐Loutsevitch Charleen M Moore Juan Carlos Lopez‐Alvarenga Betty G Dunn Donald Dudley Gene B Hubbard |
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| Institution: | 1. Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA;2. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA;3. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA;4. Department of Clinical Laboratory Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA;5. Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA |
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| Abstract: | Background Several risk factors are associated with the incidence of human stillbirths. The prevention of stillbirths in women is a pressing clinical problem. Methods We reviewed 402 pathology records of fetal loss occurring in a large baboon (Papio spp.) colony during a 15‐year period. Clinical histories of 565 female baboons with one or more fetal losses during a 20‐year period were analyzed for weight, age, and reproductive history. Results Fetal loss was most common at term (35.57%) and preterm (28.61%) and less common in the first half of gestation (11.20%) and post‐term (5.22%). Greater maternal weight, older age, history of stillbirth and higher parity were independent predictors for stillbirth. An exponential increase in the incidence of fetal loss was observed beginning at age 14 years in baboons. Conclusions Fetal loss and maternal risk factors associated with stillbirths in baboons were similar to those documented in women. |
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| Keywords: | animal model epidemiology fetal loss nonhuman primates reproduction |
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