Male infertility in a case of (Y;6) balanced reciprocal translocation. Mitotic and meiotic study |
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| Authors: | F. Viguié F. Romani J. P. Dadoune |
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| Affiliation: | (1) Service d'Histologie-Embryologie et Cytogénetique, Hôtel-Dieu de Paris, 1 Place du Parvis Notre-Dame, F-75181 Paris, France |
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| Abstract: | Summary In a 30-year-old azoospermic male, chromosome analysis revealed an apparently balanced Y-autosome reciprocal translocation, t(Y;6)(Yp6p;Yq6q). Testicular biopsy showed an arrest of spermatogenesis at the First metaphase stage of the meiosis, associated with a considerable desquamation of the germinal epithelium.Meiotic studies showed abnormalities of the sex vesicle at the pachytene stage, and the formation of a chain tetravalent at the diakinesis-metaphase I stage. Possible correlations between the translocation and the defects of spermatogenesis are discussed. |
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