LOT: a tool for linkage analysis of ordinal traits for pedigree data |
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| Authors: | Zhang Meizhuo Feng Rui Chen Xiang Hu Buqu Zhang Heping |
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| Institution: | Yale University School of Medicine, New Haven, CT 06520-8034, USA. |
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| Abstract: | SUMMARY: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. AVAILABILITY: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/ |
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