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Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety |
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| Authors: | Zoran Ratkovi? Tatjana Stanojkovi? Rastko D. Vuki?evi? Milan D. Joksovi? |
| Affiliation: | a Faculty of Sciences, University of Kragujevac, R. Domanovica 12, 34000 Kragujevac, Serbia b Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000 Belgrade, Serbia c Faculty of Chemistry, University of Belgrade, Studentski trg 16, P.O. Box. 158, 11000 Belgrade, Serbia d Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia |
| Abstract: | A series of new α,β-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MTT method. Derivative 1l containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of K562 cell lines in comparison with cisplatin as a reference compound. |
| Keywords: | Ferrocene Chalcone analogues Pyrazole Cytotoxicity |
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