Synthesis and antibacterial activity of novel enolphosphate derivatives |
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| Authors: | Claude Grison Nicolas Barthes Raphael E. Duval |
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| Affiliation: | a CEFE UMR 5175, Campus CNRS, 1919 route de Mende, 34293 Montpellier cédex 5, France
b GEVSM UMR 7565, Nancy-University, CNRS, 5 rue Albert Lebrun, 54001 Nancy cedex, France |
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| Abstract: | A new class of enolphosphates derivatives, the 1-alkenyldiphosphates, was designed and a rapid and efficient synthesis for these compounds was developed. These new molecules showed interesting in vitro antibacterial activities (MIC) against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative pathogens including Pseudomonas aeruginosa and Escherichia coli. |
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| Keywords: | Enolphosphate Perkow reaction 1-Alkenyldiphosphates Antibacterial activities |
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