Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants |
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| Authors: | Katherine Luzuriaga, Hulin Wu, Margaret McManus, Paula Britto, William Borkowsky, Sandra Burchett, Betsy Smith, Lynne Mofenson, John L. Sullivan, the PACTG Investigators&#x |
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| Affiliation: | Katherine Luzuriaga, Hulin Wu, Margaret McManus, Paula Britto, William Borkowsky, Sandra Burchett, Betsy Smith, Lynne Mofenson, John L. Sullivan, and the PACTG 356 Investigators† |
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| Abstract: | Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication. |
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