Lipid rafts and assembly of enveloped viruses |
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Authors: | Suomalainen Maarit |
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Institution: | Department of Biosciences at Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden, |
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Abstract: | The plasma membrane, late secretory pathway and endosomal compartments contain detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular processes. A number of recent reports have localized structural proteins of several enveloped viruses to rafts, thus raising the possibility that rafts also play a role in the assembly and budding of viruses, but what exactly that role might be is still unknown. |
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Keywords: | assembly budding Ebola HIV-1 influenza lipid rafts |
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