| 利多卡因对人中性粒细胞^3H—LPS特异性结合量的影响 |
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| 引用本文： | 李永荣,姚德厚.利多卡因对人中性粒细胞^3H—LPS特异性结合量的影响[J].中国应用生理学杂志,1998,14(4):372-373. |
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| 作者姓名： | 李永荣 姚德厚 |
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| 作者单位： | 成都军区总医院麻醉科 |
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| 摘 要： | 目的：探讨利多卡因对人中性粒细胞３Ｈ－ＬＰＳ特异性结合量的影响。方法：用放射配基结合法测量３Ｈ标记的ＬＰＳ与中性粒细胞的特异性结合量。结果３Ｈ－ＬＰＳ与中性粒细胞的特异性结合量随３Ｈ－ＬＰＳ的增加而增加，当３Ｈ－ＬＰＳ浓度增加到８ｎｍｏｌ／Ｌ时，中性粒细胞与３Ｈ－ＬＰＳ的特异性结合基本达到饱和程度。当加入５０ｍｍｏｌ／Ｌ利多卡因时，３Ｈ－ＬＰＳ与中性粒细胞的特异性结合量显著降低。结论：利多卡因抑制３Ｈ－ＬＰＳ与中性粒细胞结合
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| 关 键 词： | 利多卡因 中性粒细胞 ~3H-LPS |
THE EFFECTS OF LIDOCAINE ON SPECIFIC BINDING OF 3 H LPS TO HUMAN NEUTROPHILS |
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| Li Yongrong,Yao Dehou ,Guo Guilin,et al.THE EFFECTS OF LIDOCAINE ON SPECIFIC BINDING OF 3 H LPS TO HUMAN NEUTROPHILS[J].Chinese Journal of Applied Physiology,1998,14(4):372-373. |
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| Authors: | Li Yongrong Yao Dehou Guo Guilin |
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| Institution: | Li Yongrong,Yao Dehou 1,Guo Guilin,et al |
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| Abstract: | Objective: To investigate effect of lidocaine on specific binding of 3 H LPS to human neutrophils. Methods: The specific binding of 3 H LPS to human neutrophils was examined by radioligand binding assay. Results: the specific binding of 3 H LPS to human neutrophils increased with concentration of 3 H LPS, when concentration of 3 H LPS was increased to 8 nmol/L. The specific binding of 3 H LPS to human neutrophils was saturable gradually. By treatment with 50 mmol/L lidocaine, the specific binding of 3 H LPS was reduced significantly. Conclusion: lidocaine inhibits binding of LPS to human neutrophils. |
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| Keywords: | neutrophils 3 H LPS binding lidocaine |
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