| 重组人肝细胞生长因子抗四氯化碳染毒小鼠肝的保护效应 |
| |
| 引用本文： | 宫德正 邹原. 重组人肝细胞生长因子抗四氯化碳染毒小鼠肝的保护效应[J]. 中国应用生理学杂志, 1998, 14(4): 339-342 |
| |
| 作者姓名： | 宫德正 邹原 |
| |
| 作者单位： | 大连医科大学生理教研室 |
| |
| 基金项目： | 国家自然科学基金,辽宁省卫生厅科研基金 |
| |
| 摘 要： | 为检测重组人肝细胞生长因子（ｒ－ｈＨＧＦ）的保肝作用，本工作观察到ｒ－ｈＨＧＦ降低ＣＣｌ４染毒小鼠血清ＡＬＴ和ＡＳＴ升高的幅度，减轻肝组织受损的程度和防止肝细胞器的破坏，而且，ｒ－ｈＨＧＦ的这种保肝效应所需剂量极小，为ｎｇ级。根据上述资料推测，ｒ－ｈＨＧＦ为一极有效的保护小鼠肝抗ＣＣｌ４损伤的生长因子
|
| 关 键 词： | 重组人肝细胞生长因子 四氯化碳 保护作用 |
RECOMBINANT HUMAN HEPATOCYTE GROWTH FACTOR PROTECTS AGAINST ACUTE LIVER FAILURE INDUCED BY CCl 4 POISONING IN MICE |
| |
| Gong Dezheng,ZouYuan,Mei Maohua. RECOMBINANT HUMAN HEPATOCYTE GROWTH FACTOR PROTECTS AGAINST ACUTE LIVER FAILURE INDUCED BY CCl 4 POISONING IN MICE[J]. Chinese journal of applied physiology, 1998, 14(4): 339-342 |
| |
| Authors: | Gong Dezheng ZouYuan Mei Maohua |
| |
| Abstract: | To assess the protective effect of recombinant human hepatocyte growth factor ( r hHGF ) on liver, it was found the factor was capable of suppressing elevation of serum alanine transaminase and aspartate transaminase, lessning the severity of the hepatic lession and preventing destruction of the structure of organelle in hepatocyte of mice intoxicated by carbon tetrachloride. The protective action of the r hHGF appears to be a very small dose(ng). Based upon the above mentioned data, it is suggested that r hHGF is a very effective growth factor to protect mice liver against CCL 4 injury. |
| |
| Keywords: | recombinant human hepatocyte growth factor(r hHGF) carbon tetrachloride protective action |
| 本文献已被 CNKI 维普 等数据库收录！ |
