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Design, synthesis and cytotoxic evaluation of keto-C-glycoside fatty acid conjugates. |
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| Authors: | Jean Hersovici M. Idriss Bennani-Baiti Roland Montserret Charles Frayssinet Kostas Antonakis |
| Affiliation: | a Laboratoire de Chimie Organique Biologique et Spectroscopique. Institut de Recherches Scientifiques Sur le Cancer, CNRS, 94801 Villejuif, France. b Laboratoire de Pathologie Cellulaire. Institut de Recherches Scientifiques Sur le Cancer, CNRS, 94801 Villejuif, France |
| Abstract: | Keto C-glycoside-fatty acid conjugates were synthesized from 6-hydroxy 2- and 4-keto unsaturated D-C-glycosides. These compounds were tested for cytotoxic activity against LFCl2A cells (Rat hepatocarcinoma cells). The introduction of a lipid chain to 2-keto C-glycosides induced a drop in the cyctotoxic activity of these compounds. On the other hand 4-keto unsaturated C-glycoside-fatty acid conjugates possessed IC50 values of 0.7–0.001 μM with 21 being the most potent. |
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