A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines |
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| Institution: | 1. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA;2. Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA;1. Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;2. Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy;3. Cardiologic Unit, ASL of Teramo, Teramo, Italy;4. Cardiology Department, University of Brescia, Spedali Civili of Brescia, Brescia, Italy;5. Internal Medicine Division, Ospedale Angelo Bellini, Somma Lombardo, Varese, Italy |
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| Abstract: | The Cdc7 protein kinase of Saccharomyces cerevisiae is a critical regulator of several aspects of DNA metabolism and cell cycle progression. We describe the isolation of a human gene encoding a Cdc7 homolog. The Cdc7Hs protein sequence is 27% identical to that of the yeast protein, includes features unique to yeast Cdc7, and contains all conserved catalytic residues of protein kinases. The human sequence also shows significant similarity to the cyclin-dependent kinases, in accordance with evidence that yeast Cdc7 is related to the cdks. CDC7Hs is expressed in many normal tissues, but overexpressed in certain tumor types and all transformed cell lines examined. In some of the tumors tested, CDC7Hs expression correlates with expression of a proliferation marker, the histone H3 gene. In other cases, no such correlation was observed. This suggests that CDC7Hs expression may be associated with hyperproliferation in some tumors and neoplastic transformation in others. |
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