Sphingosine-induced c-jun expression: differences between sphingosine- and C2-ceramide-mediated signaling pathways |
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Authors: | Sawai Hirofumi Okazaki Toshiro Domae Naochika |
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Affiliation: | Department of Internal Medicine, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka, Japan. sawai@cc.osaka-dent.ac.jp |
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Abstract: | Sphingolipids such as ceramide and sphingosine are putative intracellular signal mediators in cell differentiation, growth inhibition and apoptosis. Previously, we reported that C2-ceramide induced c-jun expression in apoptosis of human leukemia HL-60 cells. Here we report that sphingosine also induced c-jun expression in apoptosis of HL-60 cells. Sphingosine-induced c-jun expression was stimulated by H-89, a protein kinase A inhibitor, whereas C2-ceramide-induced c-jun expression was inhibited by protein kinase C inhibitors. Furthermore, H-89 potentiated sphingosine-induced but not C2-ceramide-induced growth inhibition. These results suggest that sphingosine and C2-ceramide might induce c-jun expression and apoptosis in distinct signaling pathways. |
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