DNA-binding behavior of ruthenium(II) complexes containing both group 15 donors and 2,2':6',2'-terpyridine |
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Authors: | Sharma Sanjeev Singh Sanjay K Chandra Manish Pandey Daya Shankar |
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Institution: | Department of Chemistry, Awadhesh Pratap Singh University, Rewa 486 003 (M.P.), India. |
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Abstract: | Tetrafluoroborate salts of cationic ruthenium complexes Ru(kappa(3)-tpy)(EPh(3))(2)Cl](+) (tpy=2,2':6',2'-terpyridine; E=P, 1 or As, 2) containing both the group 15 donor ligands and tpy and their representative substitution products are reported. Weak interaction {C-H...X (X=Cl, F and pi) and pi-pi interaction} studies revealed the presence of a double helical motif in complex 1, while the complex 2 assumes a single helical motif. Intercalative mode of interaction of the complexes 1 and 2 with calf thymus DNA (ctDNA) has been supported by absorption titration studies. |
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