Involvement of leukotriene B4 in arthritis models |
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| Authors: | Tsuji F Oki K Fujisawa K Okahara A Horiuchi M Mita S |
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| Institution: | Discovery Research Division, Santen Pharmaceutical Co., Ltd., Osaka, Japan. |
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| Abstract: | We investigated the role of leukotriene B4 (LTB4) in murine arthritis models using a leukotriene A4 (LTA4) hydrolase inhibitor, SA6541. SA6541 inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo. SA6541 also inhibited LTA4-induced hyperproliferation of synovial stromal cells in vitro. These results suggest that LTB4 may play an important role in arthritis models. |
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