TNP-LPS induces an IgG anti-TNP immune response in mice. |
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| Authors: | J Humbert I Motta P Truffa-Bachi |
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| Institution: | Unité d''Immunophysiologie Moléculaire, ER N° 232 CNRS, Département d''Immunologie, Institut Pasteur, 75724 Paris Cédex 15, France |
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| Abstract: | The trinitrophenylated derivatives of lipopolysaccharide (TNP-LPS) elicit a specific anti-TNP, thymus-independent immune response in mice. After a single injection of antigen, anti-TNP antibodies of IgM and IgG isotypes are detected at the cellular and at the humoral levels, in athymic nude mice as well as in conventional (C57B1/6 × DBA/2)F1 mice. The immune sera were resolved into IgM and IgG molecules by gel filtration; both fractions showed an anti-TNP activity, thus confirming the data obtained by the cellular analysis. |
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