Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA |
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Authors: | Belmont P Alarcon K Demeunynck M Lhomme J |
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Affiliation: | LEDSS, UMR CNRS 5616/Université J. Fourier, Grenoble, France. |
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Abstract: | Cyclization of 8-bromo-9-alkylaminoethyl-adenine quantitatively affords a substituted imidazo[1,2-e]purine. The corresponding heterodimer, imidazo[1,2-e]purine-acridine, was prepared and its interaction with abasic site containing oligonucleotides was studied. |
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