Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA |
| |
| Authors: | Belmont P Alarcon K Demeunynck M Lhomme J |
| |
| Affiliation: | LEDSS, UMR CNRS 5616/Université J. Fourier, Grenoble, France. |
| |
| Abstract: | Cyclization of 8-bromo-9-alkylaminoethyl-adenine quantitatively affords a substituted imidazo[1,2-e]purine. The corresponding heterodimer, imidazo[1,2-e]purine-acridine, was prepared and its interaction with abasic site containing oligonucleotides was studied. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
