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Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives |
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| Authors: | Yu Kuo-Long Zhang Yi Civiello Rita L Trehan Ashok K Pearce Bradley C Yin Zhiwei Combrink Keith D Gulgeze H Belgin Wang Xiangdong Alan Kadow Kathleen F Cianci Christopher W Krystal Mark Meanwell Nicholas A |
| Affiliation: | Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. |
| Abstract: | Structure-activity relationships for a series of benzimidazol-2-one-based inhibitors of respiratory syncytial virus are described. These studies focused on structural variation of the benzimidazol-2-one substituent, a vector inaccessible in a series of benzotriazole derivatives on which 2 is based, and revealed a broad tolerance for substituent size and functionality. |
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