Sex differences in prefrontal hemodynamic response to mental arithmetic as assessed by near-infrared spectroscopy |
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| Authors: | Hongyu Yang Ying Wang Zhenyu Zhou Hui Gong Qingming Luo Yiwen Wang Zuhong Lu |
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| Affiliation: | 1. Institute of Human Physiology, Medical University of Gdansk, Gdansk, Poland;2. Department of Radiology Informatics and Statistics, Medical University of Gdansk, Gdansk, Poland;3. Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland;4. Department of Computer Communications, Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland;5. International Clinical Research Center, St. Anne''s University Hospital in Brno (FNUSA), Brno, Czech Republic |
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| Abstract: | Background: Sex differences in cognitive tasks have been widely investigated. With brain-imaging techniques, the functions of the brain during the performance of tasks can be examined.Objective: Mental arithmetic and near-infrared spectroscopy (NIRS) were used to assess sex differences in prefrontal area activation in a functional brain study.Methods: Healthy college students were recruited to perform 2 mental arithmetic tasks. In the first (easy) task, students had to subtract a 1-digit number from a 3-digit number. In the second (difficult) task, they had to subtract a 2-digit number from a 3-digit number. Changes in the concentration of oxygenated hemoglobin (oxy-Hgb) in the prefrontal area during the tasks were measured with NIRS.Results: Thirty students (15 men, 15 women; mean [SD] age: 24.9 [2.2] and 24.3 [2.6] years, respectively) were recruited from Southeast University, Nanjing, China, to participate in the study. The concentration of oxy-Hgb increased during both mental arithmetic tasks (difficult task vs easy task, mean [SD] % arbitrary units: 4.36 [4.38] vs 2.26 [2.82]; F1,28 = 222.80; P < 0.01). Significant interactions of task x sex (F1,28 = 82.95), time × sex (F1,28 = 34.48), task × time (F1,28 = 222.57), and task × time × sex (F1,28 = 83.09) were obtained (all, P < 0.01). However, for the 2 tasks, no significant differences between men and women were observed in the mean (SD) response time (men vs women, sec: 3.60 [0.74] vs 3.56 [0.49] for the easy task, 6.55 [0.77] vs 6.44 [0.75] for the difficult task; F1,28 = 0.67; P = NS) or accuracy rate (men vs women, %: 95.33 [7.40] vs 92.77 [8.80] for the easy task, 62.67 [28.56] vs 54.67 [18.75] for the difficult task; F1,28 = 0.54; P = NS). Male students showed neural efficiency (less prefrontal activation in subjects with better performance) during the difficult task.Conclusions: In these subjects, sex differences in prefrontal response when performing mental arithmetic were associated with the intensity of the task. Compared with men, women had greater efficiency in task performance (ie, less activation or oxygen consumption for equal performance). |
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