Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patients |
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Authors: | Rael Leonard T Bar-Or Raphael Aumann Rachel M Slone Denetta S Mains Charles W Bar-Or David |
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Institution: | Swedish Medical Center, Trauma Research Laboratory, 501 E. Hampden Avenue Rm. 4-454, Englewood, CO 80113, USA. |
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Abstract: | The amount of oxidative stress in severely traumatized patients is usually based on various individual parameters such as total antioxidants and lipid peroxidation. Serial measurements of plasma oxidation-reduction potential (ORP) in severely traumatized patients as a simple mean of assessing overall oxidative stress is described. Serial whole blood samples were obtained from multi-trauma patients (N=39) and healthy individuals (N=10). Plasma ORP in multi-trauma patients increased during the first few days of hospitalization and approached normal ORP levels upon discharge. On the ORP maxima day (5.8 days+/-0.5 SEM), a statistically significant decrease (p<0.05) was observed for negative acute phase reactants such as plasma paraoxonase-arylesterase (PON-AE) activity and total plasma protein in comparison with admission plasma levels. Monitoring ORP could be a useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment. |
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Keywords: | Oxidation-reduction potential Paraoxonase activity Oxidative stress Inflammation Trauma Plasma |
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