Discrimination of angiotensin II receptor subtype distribution in the rat brain using non-peptidic receptor antagonists |
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Authors: | B P Rowe K L Grove D L Saylor R C Speth |
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Affiliation: | Department of Physiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0002. |
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Abstract: | The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with 125I-Sar1-Ile8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AII alpha subtype) or PD123177 (designated AII beta subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AII alpha and AII beta subtypes. |
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