The primary cilium: keeper of the key to cell division |
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Authors: | Pan Junmin Snell William |
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Institution: | Department of Biological Sciences and Technologies, Tsinghua University, Haidian District, Beijing, 100084, China. |
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Abstract: | Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle. |
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