Specificity of serotoninergic involvement in the decrease of food intake induced by quipazine in the rat. |
| |
Authors: | R Samanin C Bendotti G Candelaresi S Garattini |
| |
Institution: | Istituto di Ricerche Farmacologiche “Mario Negri” Via Eritrea, 62 - 20157 MILAN, Italy |
| |
Abstract: | The effect of quipazine on brain monoamines and the significance of this interaction in its anorectic activity was studied in rats. At doses ranging from 2.5 to 10 mg/kg quipazine markedly reduced brain 5-hydroxyindolacetic acid concentrations without significant effects on steady-state levels of serotonin, noradrenaline and dopamine. Striatal levels of homovanillic acid were significantly reduced by 10 mg/kg of quipazine but not modified by a dose of 5 mg/kg. Quipazine counteracted the decrease of brain serotonin induced by fenfluramine but did not significantly modify the effect of 6-hydroxydopamine on brain nonadrenaline and dopamine. The decrease of food intake induced by 5 mg/kg of quipazine was completely prevented by pretreatment with methergoline but was not affected by an intraventricular injection of 6-hydroxydopamine or pretreatment with penfluridol, propranolol or phentolamine. The results indicate that at doses between 2.5 and 5 mg/kg quipazine specifically acts on brain serotonin and this interaction may be important for its anorectic activity. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |