Pentoxifylline |
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Authors: | J P Freitas P M Filipe |
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Institution: | (1) Faculdade de Medicina de Lisboa, Clínica Dermatológica Universitária, Av. Egas Moniz, 1600 Lisboa, Portugal |
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Abstract: | Pentoxifylline (PTX), a tri-substituted purine and xanthine derivative, has been used for several years to improve microcirculation
because of its hemorheological properties. PTX has also antifibrotic and anti-inflammatory effects. We studied the reaction
of PTX with the hydroxyl radical and superoxide anion. Hydroxyl radical was generated by a mixture of ascorbic acid, H2O2 and Fe (III)-EDTA. We evaluated the iron-dependent degradation of deoxyribose, mediated by hydroxyl radical, in the presence
of different concentrations of PTX (from 0.05 to 3 mM), measuring the degradation products of deoxyribose that react with 2-thiobarbituric acid (TBA). The reaction of PTX with
hydroxyl radical occurred with a rate constant of (1.1±0.2)×1010
M
−1/s. These results support the properties of PTX as a hydroxyl radical scavenger. Some authors verified that PTX decreases
the release of superoxide anion from activated neutrophils. We studied the effect of PTX as a scavenger of superoxide generated
in vitro by a hypoxanthine-xanthine oxidase system. PTX was not a superoxide anion scavenger in this system. |
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Keywords: | Pentoxifylline hydroxyl radical superoxide anion |
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