Role of Synthesized Organoselenium Compounds on Protection of Rat Erythrocytes from DMBA-Induced Oxidative Stress |
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Authors: | Zeliha Selamoglu Talas Ismet Yilmaz Ilknur Ozdemir Burhan Ates Yetkin Gok Bekir Cetinkaya |
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Institution: | (1) Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, 51200, Turkey;(2) Department of Chemistry, Faculty of Science and Art, Inonu University, 44280 Malatya, Turkey;(3) Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova Izmir, Turkey |
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Abstract: | Formation of free radicals is not limited to normal cellular process but also occur upon exposure to certain chemicals (polycyclic
aromatic hydrocarbon, cadmium, lead, etc.), cigarette smoke, radiation, and high-fat diet. Free-radical damage is an important
factor in many pathological and toxicological processes. Selenium, an essential micronutrient, is a associated with antioxidant
functions, physiological defense mechanisms against different diseases including several types of cancers. Search for new
selenium compounds with more chemopreventive activities and less toxicities are in progress. In addition, there has been a
growing interest in the synthesis of organoselenium compounds with respect to their use in enzymology and bioorganic chemistry.
In the present study, adult female Wistar rats were treated with 7,12-dimethylbenza]anthracene (DMBA) and the organoselenium
compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (Se I) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Se II)] in determined doses. The protective effects of synthetic organoselenium compounds
(Se I and Se II) against DMBA-induced changes in antioxidant enzyme (superoxide dismutase, glutathione peroxidase (GSH-Px),
catalase (CAT), glutathione reductase (GR)) activities, total GSH, and malondialdehyde (MDA) levels of rat erythrocyte were
investigated. The DMBA-treated group exhibited significant decreases in the levels of erythrocyte GSH-Px, CAT, and GR activities,
an increase in MDA levels, and a decrease in total GSH level compared to the control. Se I and Se II fully or partially restored
enzyme activity. Lipid peroxidation was also decreased in Se-I- and Se-II-treated groups. |
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Keywords: | Erythrocyte Oxidative stress Rat Synthetic organoselenium compounds |
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