Histone methyltransferases in cancer |
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| Authors: | Mareike Albert Kristian Helin |
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| Institution: | 1. Department of Biochemistry and Molecular Biology, Tianjin Key Laboratory of Medical Epigenetics, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, 300070 Tianjin, China;2. Department of Chemistry, Nankai University, 300071 Tianjin, China;3. Institut für Biochemie und Molekularbiologie, Universität Freiburg, Stefan-Meier-Straße 17, 79104 Freiburg, Germany;4. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Jungong Road No. 516, 200093 Shanghai, China;1. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA;2. Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, CA 94158, USA;3. Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA;1. Molecular Biology and Biochemistry Graduate Program, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA;2. Oncology Research Institute and Department of Pathology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA |
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| Abstract: | Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action. |
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