Mitochondrial dynamics in model organisms: What yeasts,worms and flies have taught us about fusion and fission of mitochondria |
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| Authors: | Benedikt Westermann |
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| Affiliation: | 1. CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, UPR 9080, 13 rue Pierre et Marie Curie, F-75005, Paris, France;2. Laboratoire de Biologie Cellulaire et Moléculaire des Eucaryotes, Sorbonne Université, CNRS, UMR 8226, France;3. Institut de Biologie Physico-Chimique-Fondation Edmond de Rothschild, PSL Research University, Paris, France;1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060 Guangzhou, China;2. Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510530 Guangzhou, China;3. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | Mitochondrial fusion and fission are important for a great variety of cellular functions, including energy metabolism, development, aging and cell death. Many of the core components mediating mitochondrial dynamics in human cells have been first identified and mechanistically analyzed in model organisms, such as Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In particular, the functions of FZO/mitofusin and Mgm1/EAT-3/OPA1 in fusion and Dnm1/DRP1 in fission have been remarkably well conserved in yeasts, worms, flies and mammals. On the other hand, mechanisms to coordinate and regulate the activity of these molecular machines appear to be more diverse in different organisms. Here, I will discuss how S. cerevisiae, C. elegans and Drosophila have contributed to our current understanding of the cellular machineries mediating the dynamic behaviour of mitochondria. |
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