Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis |
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| Authors: | Alexander Swidsinski Yvonne Dörffel Vera Loening-Baucke Werner Mendling Johannes Schilling Jennifer L. Patterson Hans Verstraelen |
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| Affiliation: | 1. Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany and Department of Medicine, Section of Gastroenterology, Hepatology and Endocrinology, Charité Universitätsmedizin Berlin, CCM, 10117 Berlin, Germany;2. Outpatient Clinic, Luisenstr. 11-13, Charité Universitätsmedizin Berlin, CCM, 10117 Berlin, Germany;3. Vivantes Kliniken for Gynaecologic and Obstetrics am Urban and im Friedrichshain, Dieffenbachstraße 1, 10967 Berlin, Germany;4. Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA;5. Department of Obstetrics and Gynaecology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium;1. Department of Environmental Health Sciences, School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea;2. Department of Public Health Science, School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea;3. Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea;4. N-Bio, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea;5. KoBioLabs, Inc., 1 Gwanak-ro, Gwanak-gu, Bldg 220, Rm 630, Seoul 151-742, Korea;1. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;2. Department of Virology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;3. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;4. Department of Gynecology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;5. Department of Midwifery, Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
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| Abstract: | Recent data point at the similarity between the perianal and vaginal microflora in terms of Lactobacillus species involved. Bacterial vaginosis, the most common perturbation of the vaginal microflora involving primarily overgrowth of Gardnerella vaginalis, has also been suggested to involve a recto-vaginal pathway. We addressed this issue with regard to bacteria of the Bifidobacteriaceae family. In particular, we investigated the putative concordance of the presence of G. vaginalis and a series of Bifidobacteria between the perianal and vaginal microflora in 10 patients with bacterial vaginosis through multicolor fluorescence in situ hybridization analysis of desquamated epithelial cells.G. vaginalis was found in a biofilm mode of growth at the perianal and vaginal sites. In most women at least one of the following species was detected perianally: Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium breves, Bifidobacterium bifidum and Bifidobacterium catenulatum. At the vaginal site, none of these Bifidobacteria was found.We conclude that bacterial vaginosis does not occur as a result of simple growth per continuum of perianal bacteria. Only some species originating from the intestinal tract do display pronounced vaginotropism, like G. vaginalis, whereas many other species do not. |
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