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Restoring chromatin after replication: How new and old histone marks come together
Authors:Zuzana Jasencakova  Anja Groth
Affiliation:1. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JR, UK;2. Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093-0670, USA;1. Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA;2. Department of Pediatrics, Columbia University, New York, NY 10032, USA;3. Department of Genetics and Development, Columbia University, New York, NY 10032, USA;1. Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK;2. MS Bioworks, 3950 Varsity Drive, Ann Arbor, MI 48108, USA;3. Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, 4301 W. Markham #776, Little Rock, AR 72205, USA;4. Research Center for Epigenetic Disease, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan;1. State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;3. School of Life Sciences, Tsinghua University, Beijing 100084, China;1. Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;2. The Novo Nordisk Center for Protein Research (CPR), University of Copenhagen, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;1. Epigenetics & Cell Fate Centre, UMR7216 CNRS, Paris Diderot University, Sorbonne Paris Cité, F-75013 Paris, France;2. Laboratory of Nuclear Dynamics, UMR3664 CNRS, Institut Curie, PSL Research University, F-75005 Paris, France;3. Plateforme Imagerie Cellulaire et Tissulaire-Infrastructure en Biologie Santé et Agronomie, UMR3215 CNRS/U934 INSERM, Institut Curie, PSL Research University, F-75005 Paris, France;4. Team Chromatin Assembly, Nuclear Domains, Virus, Institut NeuroMyoGène, LabEx DEVweCAN, Université Claude Bernard Lyon 1, UMR5310 CNRS/U1217 INSERM, F-69100 Lyon, France
Abstract:In dividing cells genome stability and function rely on faithful transmission of both DNA sequence and its organization into chromatin. In the course of DNA replication chromatin undergoes transient genome-wide disruption followed by restoration on new DNA. This involves tight coordination of DNA replication and chromatin assembly processes in time and space. Dynamic recycling and de novo deposition of histones are fundamental for chromatin restoration. Histone post-translational modifications (PTMs) are thought to have a causal role in establishing distinct chromatin structures. Here we discuss PTMs present on new and parental histones and how they influence genome stability and restoration of epigenetically defined domains. Newly deposited histones must change their signature in the process of chromatin restoration, this may occur in a step-wise fashion involving replication-coupled processes and information from recycled parental histones.
Keywords:
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