Gentamycin inhibits the growth of Malassezia pachydermatis in culture |
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| Authors: | Carmen Aspíroz Yolanda Gilaberte Antonio Rezusta Teun Boekhout Ma Carmen Rubio |
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| Institution: | 1. Servicio de Microbiología, Hospital Royo Villanova, Zaragoza, Spain;2. Servicio de Microbiología, Hospital Miguel Server, Zaragoza, Instituto de Ciencias de la Salud de Aragón, Spain;3. Servicio de Dermatología, Hospital San Jorge, Huesca, Spain;4. Centraalbureau voor Schimmelcultures, Utrecht, the Netherlands;5. Servicio de Microbiología, Hospital Clínico Universitario, Zaragoza, Spain |
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| Abstract: | BackgroundMalassezia pachydermatis is a yeast of importance in both veterinary and human medicine.AimsTo know if M. pachydermatis grow on micological media with high concentrations of gentamycin.MethodsTwenty M. pachydermatis strains were streaked on Sabouraud Dextrose Agar plates with different concentrations of gentamycin.ResultsAll isolates were inhibited when high concentrations of gentamycin were added.ConclusionsThe use of plates with high concentrations of gentamycin can lead to some important misdiagnoses: firstly, false-negative cultures, and secondly, an erroneous classification of M. pachydermatis as a lipid-dependent species. Morever, all of this could be useful in two therapeutic fields: i) in animals, topical gentamycin could be an efficacious treatment for a disease such as external otitis in dogs; ii) in humans, we hypothesize that gentamycin could be regarded as a possible therapy (“antibiotic-lock”) for catheter-associated Malassezia spp. infections. |
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