Detection of resistance genes and susceptibility patterns in Bacteroides and Parabacteroides strains |
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| Authors: | Renata F. Boente Livia Q. Ferreira Laís S. Falcão Karla R. Miranda Priscilla L.S. Guimarães Joaquim Santos-Filho Jessica M.B.D. Vieira David E. Barroso Jean-Philippe Emond Eliane O. Ferreira Geraldo R. Paula Regina M.C.P. Domingues |
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| Affiliation: | 1. Departamento de Microbiologia Médica, Instituto de Microbiologia Prof. Paulo de Góes/UFRJ, Laboratório de Biologia de Anaeróbios – Avenida Carlos Chagas Filho, 373, Centro de Ciências da Saúde, Bloco I, 2° andar, Ilha do Fundão, Cidade Universitária, Rio de Janeiro/RJ, 21941-902, Brasil;2. Laboratório de Sistemática Bioquímica, Instituto Oswaldo Cruz, FIOCRUZ. Avenida Brasil, 4365 – Manguinhos, Rio de Janeiro/RJ, 21040-900, Brasil;3. Centre Hospitalier Intercommunal, 40, Allée de la Source – 94195 Villeneuve-Saint-Georges Cedex, Paris, France;4. Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia/UFF, Rua Dr. Mário Viana, 523, Santa Rosa, Niterói/RJ, Brazil;1. Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada;2. Department of Medicine and Department of Infectious Diseases and Pathology, University of Florida, Gainesville, FL 32611, USA;1. Aix-Marseille Université, URMITE, UM63, CNRS7278, IRD198, Inserm 1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France;2. Clinical Microbiology Laboratory, Saint George University Hospital, Faculty of Health Sciences, University of Balamand, Beirut, Lebanon;1. Beckman Coulter Diagnostics, Inc., West Sacramento, CA, USA;2. Weill Cornell Medical College/New York-Presbyterian Hospital, New York, NY, USA;3. Centers for Disease Control and Prevention Atlanta, GA, USA;4. R.M. Alden Research Laboratory, Culver City, CA, USA;5. Novartis Institutes for Biomedical Research, Cambridge, MA, USA;6. International Health Management Associates Inc., Schaumburg, IL, USA;7. Loyola University Medical Center, Maywood, IL, USA;8. Tufts Medical Center, Boston, MA, USA;9. New York Presbyterian Hospital, New York, NY, USA;10. Thermo Fisher Scientific, Cleveland, OH, USA;11. Laboratory Specialists, Inc. Westlake, OH, USA;12. UCLA School of Medicine, Westwood, CA, USA |
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| Abstract: | Susceptibility to five antimicrobials was determined for Bacteroides spp. (n = 52) and Parabacteroides distasonis (n = 8). All isolates were susceptible to metronidazole. The resistance rates to ampicillin, cefoxitin, tetracycline and clindamycin were 98%, 9.6%, 65.3% and 19.2% of the Bacteroides strains, respectively. The genes cepA, cfiA, cfxA, tetQ, ermF and nim were found in 69.2%, 17.3% 9.6%, 50%, 7.7% and 3.8% for these strains respectively. All P. distasonis strains were resistant to ampicilin. Cefoxitin, tetracycline and clindamycin resistance rates were 75%, 87.5% and 50%, respectively. The ermF and nim genes were absent and 37.5%, 12.5%, 12.5% and 87.5% of this strains possessed cepA, cfiA, cfxA and tetQ genes, respectively. Ten cfiA gene positive strains of Bacteroides and Parabacteroides were submitted to E-test with imipenem and amoxicillin–clavulanate. The resistance rate to imipenem was 4.1% and 8.3% to amoxicillin–clavulanate. This feature is for the first time described in Brazil. |
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