The pleiotropic effects of 33258-Hoechst on the cell cycle in Chinese hamster cells in vitro |
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| Authors: | J Hirschberg U Lavi R Goitein M Marcus |
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| Institution: | Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel |
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| Abstract: | The fluorochrome 33258-Hoechst which binds to double-stranded DNA (dsDNA) has been previously shown to inhibit in several mammalian cell cultures the condensation of chromosomes in phase G2 and early mitosis. We have now found that this drug affects the cell cycle of Chinese hamster cells grown in vitro in several other ways. In cells treated with the drug, phase G2 is prolonged, the rate of DNA replication is drastically reduced and the cells are arrested most probably at very late S phase. |
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