Lactate dehydrogenase isoenzymes: distribution in fast-twitch red, fast-twitch white, and slow-twitch intermediate fibers of guinea pig skeletal muscle |
| |
| Authors: | J B Peter S Sawaki R J Barnard V R Edgerton C A Gillespie |
| |
| Affiliation: | 1. University of California San Diego, Department of Medicine, 9500 Gillman Drive, San Diego, CA 92093, USA;2. University of California San Diego, Department of Neurosciences, 9500 Gillman Drive, San Diego, CA 92093, USA;3. University of California San Diego, Department of Surgery, 9500 Gillman Drive, San Diego, CA 92093, USA;4. The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;1. Department of Neurosurgery, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA;2. Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, 175 N. Medical Drive East, Salt, Lake City, UT 84132, USA;3. Department of Neurosurgery, Washington University in St. Louis, 660 S. Euclid, Box 8057, St. Louis, MO 63110, USA;4. Department of Neurosurgery, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 301, MSC 606, Charleston, SC 29425-6160, USA |
| |
| Abstract: | Lactate dehydrogenase activity and LDH isoenzyme distribution were determined in supernatants of skeletal muscles consisting predominately of fast-twitch red, fast-twitch white, or slow-twitch intermediate fibers. The LDH activity was highest in the fast-twitch white. The activity in the fast-twitch red was significantly lower than in the fast-twitch white but significantly greater than in slow-twitch intermediate muscle or the heart. LDH5 was found to be the predominant isoenzyme in both the fast-twitch white and fast-twitch red fibers whereas LDH1 predominated in both the slow-twitch intermediate fibers and the heart. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
