| 凋亡调控基因BCL2家族研究的新进展 |
| |
| 引用本文： | 刘陶文. 凋亡调控基因BCL2家族研究的新进展[J]. 生物化学与生物物理进展, 1999, 26(3): 216-219 |
| |
| 作者姓名： | 刘陶文 |
| |
| 作者单位： | 广西壮族自治区第二人民医院肿瘤血液学研究所,桂林,541002. |
| |
| 摘 要： | 凋亡的调控是细胞生理死亡和肿瘤发生的重要机制. 对各种刺激诱导下细胞凋亡机制的分析有助于深入了解肿瘤细胞生物学及发现新的治疗对策.凋亡调控基因BCL2家族成员可分为凋亡阻遏基因和凋亡促进基因.这些基因编码的蛋白质分子通过组成和/或影响同二聚体与异二聚体的不同比例而介导其对细胞存活的生物学效应.
|
| 关 键 词： | 凋亡，BCL2家族，机制，BCL2/BAX |
| 收稿时间： | 1998-01-02 |
| 修稿时间： | 1998-06-08 |
Recent Advances in Apoptotic Modulating Gene BCL2 Family |
| |
| LIU Tao-Wen. Recent Advances in Apoptotic Modulating Gene BCL2 Family[J]. Progress In Biochemistry and Biophysics, 1999, 26(3): 216-219 |
| |
| Authors: | LIU Tao-Wen |
| |
| Affiliation: | Institute of Bioengineering,Guilin Medical College,Guilin 541004,China |
| |
| Abstract: | The regulation of apoptosis is an essential mechanism for physiological cell death and tumorigenesis. The analysis of the genetic machanisms reponsible for susceptibility to or protection from apoptosis stimuli not only enables us to gaininsight into tumor cell biology,but may also prove useful in the development of new therapeutic strategies. Among the proteins coded by the genes of BCL2 family,BCL2,BCL-XL,MCL-1,CED-9,BAG-1,E1B-194 and A1 act as death repressors, whereas BAX, BAk, BCL-Xs and BAD promote cell death. These different functions were shown to be mediated by homodimerzation/heterodimerization of the various family members. Therefore a critical balance between molecules above may determine the fate of cells in reponse to apoptosis-inducing conditions. |
| |
| Keywords: | apoptosis BCL2 family mechanism BCL2/BAX |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
|
点击此处可从《生物化学与生物物理进展》下载全文 |
|
