Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus |
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Authors: | Andrea Molnár István Gyurján Éva Korpos Adrienn Borsy Viktor Stéger Zsuzsanna Buzás Ibolya Kiss Zoltán Zomborszky Péter Papp Ferenc Deák László Orosz |
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Institution: | 1. Institute of Genetics, Agricultural Biotechnology Center, Szent-Gy?rgyi A. u. 4., 2100, G?d?ll?, Hungary 2. Department of Genetics, E?tv?s Loránd University and Research Group for Molecular Genetics of the Hungarian Academy of Sciences, Pázmány P. sétány I/C, 1117, Budapest, Hungary 3. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, 6701, Szeged, Hungary 4. Department of Fish and Pet Animal Breeding, Faculty of Animal Science, University of Kaposvár, P.O. Box 16, 7401, Kaposvár, Hungary
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Abstract: | Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental
biology, with significant medical implications. Here, we have identified the expression patterns for 36 genes that were characteristic
or dominant in the consecutive cell differentiation zones (mesenchyme, precartilage, cartilage) of the tip section of the
developing velvet antler of red deer Cervus elaphus. Two major functional groups of these genes clearly outlined: six genes linked to high metabolic demand and other five to
tumor biology. Our study demonstrates the advantages of the antler as a source of mesenchymal markers, for distinguishing
precartilage and cartilage by different gene expression patterns and for identifying genes involved in the robust bone development,
a striking feature of the growing antler. Putative roles for “antler” genes that encode α-tropomyosine (tpm1), transgelin
(tagln), annexin 2 (anxa2), phosphatidylethanolamine-binding protein (pebp) and apolipoprotein D (apoD) in intense but still
controlled tissue proliferation are discussed. |
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Keywords: | Red deer Antler development Robust bone development AFLP-based differential display Tumor associated genes |
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