Europium complexes of 1,10-phenanthrolines: Their inclusion in liposomes and cytotoxicity |
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| Authors: | I. A. Boldyrev G. P. Gaenko E. V. Moiseeva T. Deligeorgiev S. Kaloyanova N. Lesev A. Vasilev J. G. Molotkovsky |
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| Affiliation: | 1. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia
2. Department of Applied Organic Chemistry, Faculty of Chemistry, University of Sofia, Sofia, Bulgaria
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| Abstract: | Cytotoxic effect of a series of 1,10-phenanthroline coordination complexes with europium tris-β-diketonate (EuCs) against HBL-100 human breast carcinoma cells was determined. Cytotoxicity of liposomal formulation of V12, the most active EuC, was also studied. In vivo testing of this formulation on a started ASF-LL lethal murine model of T-cell leukemic lymphoma showed that the inclusion of V12 in liposomes did not result in enhancement of its antitumor activity in a local mode of administration. |
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