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Noninvasive estimation of the oxygen status of experimental tumors by diffuse optical spectroscopy |
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| Authors: | A. G. Orlova A. V. Maslennikova G. Yu. Golubyatnikov V. A. Kamensky N. M. Shakhova A. A. Babaev L. B. Snopova I. P. Ivanova V. I. Plekhanov T. I. Pryanikova I. V. Turchin |
| Affiliation: | 1. Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod, 603950, Russia 2. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia 3. Lobachevsky State University, Nizhny Novgorod, Russia |
| Abstract: | The potentialities of diffuse optical spectroscopy for noninvasive estimation of the oxygen status of experimental tumors have been demonstrated. The distribution of total, oxygenated, and deoxygenated hemoglobin, as well as the level of oxygen saturation of blood have been assessed using two tumor models differing in the histological structure and functional characteristics. The results obtained by the optical method have been verified by immunohistochemical examination of tissue specimens with an exogenous hypoxia marker pimonidazole. |
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