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Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes |
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| Authors: | Julianne Meyne Robert J Baker Holly H Hobart T C Hsu Oliver A Ryder Oscar G Ward John E Wiley Doris H Wurster-Hill Terry L Yates Robert K Moyzis |
| Institution: | (1) Genetics Group, Los Alamos National Laboratory, 87545 Los Alamos, NM, USA;(2) Department of Biological Sciences, Texas Tech University, Lubbock, TX, USA;(3) Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA;(4) Department of Cell Biology, The University of Texas M.D. Anderson Cancer Center, 77030 Houston, TX, USA;(5) Center for Reproduction of Endangered Species, The Zoological Society of San Diego, San Diego, CA, USA;(6) Department of Pediatrics, School of Medicine, East Carolina University, Greenville, NC, USA;(7) Department of Pathology, Dartmouth Medical School, Hanover, NH, USA;(8) Department of Biology, University of New Mexico, Albuquerque, NM, USA |
| Abstract: | The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres. |
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