Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker |
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Authors: | Aviñó Anna Mazzini Stefania Ferreira Rubén Eritja Ramon |
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Affiliation: | Institute for Research in Biomedicine, Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), CSIC, Baldiri Reixac 10, E-08028 Barcelona, Spain. aaagma@cid.csic.es |
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Abstract: | Oligonucleotide conjugates containing acridine and quindoline derivatives linked through a threoninol molecule were synthesized. We showed that these conjugates formed duplexes and quadruplexes with higher thermal stability than the corresponding unmodified oligonucleotides. When acridine is located in the middle of the sequence, DNA duplexes have a similar stability independently of the natural base present in front of acridine. Self-complementary oligonucleotides and thrombin binding aptamers (TBA) carrying the acridine and quindoline molecules are studied by NMR. |
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