Regulation of cyclic AMP levels in canine thyroid slices by alpha-adrenergic action. |
| |
Authors: | K Yamashita S Yamashita E Ogata |
| |
Affiliation: | Department of Medicine, University of Tsukuba, Niiharigun, Ibaraki-ken, 300-31, Japan |
| |
Abstract: | In an attempt to clarify the role of adrenergic receptors in metabolic responses, interaction of norepinephrine with TSH was studied in canine thyroid slices with regard to cyclic AMP levels. Norepinephrine caused a very rapid (within 1 min), but quite transient increase in cyclic AMP levels. The elevation of cyclic AMP levels induced by TSH was markedly inhibited by norepinephrine. Phentolamine, an α-adrenergic blocker, not only prevented the decline of cyclic AMP levels that followed the rise by norepinephrine, but also abolished the norepinephrine effect on the TSH-induced elevation of cyclic AMP levels. Propranolol, a β-adrenergic blocker, exhibited no such effects. These results indicate that the α-adrenergic receptors control cyclic AMP levels in the thyroid gland. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|