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In vitro effects of aminoglycosides and cephalosporins on rat kidney lysosomes] |
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| Authors: | J P Morin J P Fillastre R Vaillant |
| Abstract: | The study of aminoglycoside and cephalosporin antibiotics was performed using a subcellular system in vitro. Lysosomes were purified from rat kidney tissue homogenates by a linear sucrose gradient centrifugation technique. The lysosomal membrane integrity was estimated by measuring the free N-acetyl-beta-D-glycosiminidase activity in the incubation medium. A scale of toxicity was established for eleven aminoglycosides and four cephalosporins. |
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