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We deal in this paper with the concept of genetic regulation network. The genes expression observed through the bio-array imaging allows the geneticist to obtain the intergenic interaction matrix W of the network. The interaction graph G associated to W presents in general interesting features like connected components, gardens of Eden, positive and negative circuits (or loops), and minimal components having 1 positive and 1 negative loop called regulons. Depending on parameters values like the connectivity coefficient K(W) and the mean inhibition weight I(W), the genetic regulation network can present several dynamical behaviours (fixed configuration, limit cycle of configurations) called attractors, when the observation time increases. We give some examples of such genetic regulation networks and analyse their dynamical properties and their biological consequences. 相似文献
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A regulatory protein HrpXo of Xanthomonas oryzae pv. oryzae, the causal agent of bacterial leaf blight of rice, is known to control the expression of hrp genes that encode components of a type III secretion system and of some effector protein genes. In this study, we screened novel HrpXo regulons from the genome database of X. oryzae pv. oryzae, searching for ORFs preceded by two predicted sequence motifs, a plant-inducible promoter box-like sequence and a -10 box-like sequence. Using a gus reporter system, nine of 15 ORF candidates were expressed HrpXo dependently. We also showed by base-substituted mutagenesis that both motifs are essential for the expression of the genes. 相似文献
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Maria Eleni Kastriti Louis Faure Dorothea Von Ahsen Thibault Gerald Bouderlique Johan Bostrm Tatiana Solovieva Cameron Jackson Marianne Bronner Dies Meijer Saida Hadjab Francois Lallemend Alek Erickson Marketa Kaucka Viacheslav Dyachuk Thomas Perlmann Laura Lahti Jan Krivanek JeanFrancois Brunet Kaj Fried Igor Adameyko 《The EMBO journal》2022,41(17)
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