New therapy with XLQ® to suppress chronic prostatitis through its anti-inflammatory and antioxidative activities

Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions of XLQ^® in chronic nonbacterial prostatitis using a complete Freund's adjuvant-induced rat model. Prostates and blood samples were collected for further evaluation after oral gavage with XLQ ^® or a vehicle for 4 weeks. The results showed that XLQ ^® significantly decreased the prostate index, ameliorated the histopathologic changes, and reduced CD3+ and CD45+ cell infiltration in the prostate stroma. Further study showed that XLQ ^® suppressed the expression of proinflammatory cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-17A, monocyte chemoattractant protein-1, and tumor necrosis factor-α. XLQ ^® showed a strong antioxidant capacity by enhancing the activities of antioxidative enzymes (e.g., total superoxide dismutase, catalase, and glutathione peroxidase) and decreasing the level of lipid peroxidation products (malondialdehyde). Moreover, XLQ ^® can suppress the activation of nuclear factor-κB and P38-mitogen-activated protein kinase signaling pathways. In summary, XLQ ^® has affirmative effects on chronic prostatitis, which could be attributed to its anti-inflammatory and antioxidative capacities. On the basis of these results, XLQ ^® can be developed as an effective and safe therapy for chronic prostatitis.     

慢性非细菌性前列腺炎/慢性骨盆疼痛综合征患者的尿动力学检查

目的:探讨尿动力学检查在了解慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(Chronicabacterialprostatitis/chronicpelvicpain syndrome,CPPS)患者中下尿路症状(LUTS)产生原因的作用。方法:对36例难治性慢性前列腺炎/盆腔疼痛综合征患者行尿流动力学压力-流率测定,同步测定膀胱压、逼尿肌压、同步肌电图测定,了解其症状产生的原因。结果:36例患者中,尿动力学证实膀胱出口梗阻14例(39%);逼尿肌过度活动者8例,其中有7例与BOO同时存在;假性逼尿肌尿道外括约肌协同失调6例(16.7%);逼尿肌收缩力低下者5例(13.9%)。结论:对难治性CPPS患者进行尿动力学检查有助于对此类患者LUTS产生的原因进行鉴别,从而可以采取有针对性的治疗。     

茅莓对大鼠非细菌性前列腺炎的影响

采用角叉菜胶和消痔灵制备大鼠非细菌性前列腺炎病理模型,研究茅莓提取物对大鼠非细菌性前列腺炎的影响。取前列腺炎模型大鼠随机分为模型对照组、茅莓水提物高(5.0 g/kg)、低剂量组(2.5 g/kg)、茅莓醇提物高(5.0 g/kg)、低剂量组(2.5 g/kg),各组灌胃给药每天2次,连续28 d,观察大鼠前列腺湿重、指数及病理组织检查等指标的变化。结果表明:茅莓能抑制前列腺炎模型大鼠前列腺腺体增重(P<0.05),减轻炎性细胞浸润和损伤(P<0.05),对大鼠非细菌性前列腺炎有一定的治疗作用。     

单纯治疗慢性前列腺炎对其合并早泄的影响

目的:探讨单纯治疗慢性前列腺炎对其合并早泄的影响。方法:选择372例前列腺炎继发早泄的患者进行单纯针对前列腺炎的治疗,评价前列腺炎的治疗效果(包括前列腺炎症状评分(NIH-CPSI)、前列腺液常规等)及早泄的治疗效果(包括患者性生活满意度评分、配偶性生活满意度评分及阴道内射精潜伏期等)。结果:慢性前列腺炎经综合治疗后,患者的NIH-CPSI评分及前列腺液白细胞计数均显著降低(P0.05)。前列腺炎治愈或好转后,大多数患者的早泄情况得到明显改善,患者性生活满意度、配偶性生活满意度均较治疗前显著提高,阴道内射精潜伏期亦较治疗前明显延长,差异均具有统计学意义(P0.05)。结论:单纯治疗慢性前列腺炎继可使大部分患者并发的早泄明显改善,而对少数前列腺炎好转后早泄症状改善不明显者,可联合应用SSRIs等药物治疗。     

慢性非细菌性前列腺炎／慢性骨盆疼痛综合征患者的尿动力学检查

目的：探讨尿动力学检查在了解慢性非细菌性前列腺炎／慢性骨盆疼痛综合征 （Chronic abacterial prostatitis/chronic pelvic pain syndrome, CPPS） 患者中下尿路症状（LUTS）产生原因的作用。方法：对36例难治胜慢性前列腺炎／盆腔疼痛综合征患者行尿流动力学压力-流率测定,同步测定膀胱压、逼尿肌压、同步肌电图测定,了解其症状产生的原因。结果：36例患者中,尿动力学证实膀胱出口梗阻14例（39％）;逼尿肌过度活动者8例,其中有7例与BOO同时存在;假性逼尿肌尿道外括约肌协同失调6例（16．7％）;逼尿肌收缩力低下者5例（13．9％）。结论：对难治性CPPS患者进行尿动力学检查有助于对此类患者LUTS产生的原因进行鉴别。从而可以采取有针对性的治疗。     

Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis

BackgroundThe National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.MethodWe analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS).ResultsMetal concentration combined clinical characteristics analysis suggested that average level of Zn, Ca, Mg were significantly lower in the EPS of patients with category IV prostatitis (P-value< 0.000), while Cu level raised obviously (P-value< 0.000). And in the serum, mean concentrations of Ca was also found to increase significantly in the patients with category IV prostatitis compared to healthy controls. Moreover, the correlation analysis indicated that age showed a positive correlation with EPS Zn, Ca, Mg concentration (P-value< 0.05), while albumin correlates with EPS Zn, Ca, Mg concentration reversely (P-value< 0.05) in patients with category IV prostatitis.ConclusionOur report revealed that determination of the metal elements zinc, copper, calcium and magnesium in the serum and EPS could be a new and promising strategy for the rapid diagnosis of category IV prostatitis.     

甲磺酸多沙唑嗪控释片联合中药坐浴治疗老年非细菌性前列腺炎的临床疗效

目的:探讨甲磺酸多沙唑嗪控释片联合中药坐浴治疗老年非细菌性前列腺炎的临床疗效。方法:选取我院泌尿男科收治的老年非细菌性前列腺炎患者60例,随机分配为实验组和对照组,每组各30例,对照组患者使用甲磺酸多沙唑嗪控释片进行治疗,实验组患者在对照组的治疗基础上加用中药坐浴进行治疗,两组患者均治疗1个月。治疗结束后对患者前列腺液中的WBC水平进行检测,并应用美国国家卫生研究院慢性前列腺炎症状指数(NIH-CPSI)表对患者的前列腺功能进行评分,同时比较治疗结束后两组患者临床总有效率。结果:与治疗前相比,两组患者WBC计数及NIH-CPSI评分均有所降低(P0.05);与对照组相比,实验组患者治疗后WBC计数及NIH-CPSI评分较低(P0.05);临床总有效率较高(P0.05)。结论:甲磺酸多沙唑嗪控释片联合中药坐浴能够提高老年非细菌性前列腺炎患者的前列腺功能,降低炎症反应,临床疗效更好。     

泄浊通淋汤联合左氧氟沙星对慢性细菌性前列腺炎患者 IL-2、CRP和TNF-γ水平的影响

目的观察泄浊通淋汤联合左氧氟沙星对慢性细菌性前列腺炎患者IL-2、CRP和TNF-γ水平的影响。方法选择116例湿热下注型慢性细菌性前列腺炎患者为研究对象,随机分为研究组和对照组各58例。对照组患者口服左氧氟沙星治疗,研究组在对照组治疗的基础上口服泄浊通淋汤,两组患者均治疗4周。比较两组患者治疗效果、治疗前后EPS-WBC个数、NIH-CPSI评分以及血清IL-2、CRP和TNF-γ含量和不良反应发生情况。结果研究组患者治疗总有效率显著高于对照组(93.10%vs 77.59%,χ~2=5.583,P0.05)。研究组患者治疗后EPS-WBC个数、NIH-CPSI评分、血清IL-2、CRP和TNF-γ含量均低于对照组(均P0.05)。结论泄浊通淋汤联合左氧氟沙星可有效降低慢性细菌性前列腺炎患者EPS-WBC数量,改善NIH-CPSI评分,降低血清中IL-2、CRP和TNF-γ含量,且治疗期间不良反应少,值得临床推广应用。     

慢性前列腺炎（Ⅱ、Ⅲ型）所致不育症的临床分析

目的观察综合疗法治疗慢性前列腺炎（Ⅱ、Ⅲ型）所致不育症的疗效。方法将120例慢性前列腺炎（Ⅱ、Ⅲ型）所致不育症的患者随机分为A组、B组、C组。A组（综合治疗组）,B组（中西药结合治疗组）,C组（西药治疗组）。观察3组治疗前、后前列腺液、精液各项指标的变化情况。结果 A组治愈26例,显效8例,有效4例,无效2例,总有效率95%;B组分别为14例,8例,6例,12例和70%;C组分别为12例,10例,5例,13例和67.5%。经Ridit分析,A组与B组比较,P〈0.01,与C组比较,P〈0.01;B组与C组比较,P〉0.01。结论综合疗法治疗慢性前列腺炎（Ⅱ、Ⅲ型）所致不育症的效果较好,并能改善精液质量和精子的活动能力,提高受孕率。     

性病后慢性前列腺炎病原微生物分析

本文对性病后慢性前列腺炎病原微生物进行了研究。９０例患者前列腺液支原体检出率为２４．４４％（２２／９０）,其中解脲支原体为２２．００％（１８／９０）,人型支原体为４．４４％（４／９０）。另一组２３２例患者进行前列腺液细菌培养鉴定,总检出率为４２．７％（９９／２３２）,以金黄色葡萄球菌为主２４．５％（５７／２３２）,其它菌依次为表皮葡萄球菌７．３％（１７／２３２）,肠球菌４．３％（１０／２３２）,非发酵菌２．６％（６／２３２）,肠杆菌科细菌２．２％（５／２３２）和Ａ群链球菌１．７％（４／２３２）。作者认为,性病后慢性前列腺炎可能为急性尿道炎期,由于治疗不彻底或忽略非特异性性病病原菌的治疗而使条件致病菌上行感染所致。