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Inga-Lill Mårtensson Nina Almqvist Ola Grimsholm Angelina I. Bernardi 《FEBS letters》2010,584(12):2572-141
B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. 相似文献
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《Cell cycle (Georgetown, Tex.)》2013,12(22):4129-4134
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