Structure Elucidation of Two New Norlignans from Anemone vitifolia and Their Anti‐Inflammatory Activities

Two new norlignans together with two known phenylpropanoids were isolated from the whole herb of Anemone vitifolia. All compounds were reported from this plant for the first time. The structures of these compounds were identified by comprehensive HR‐ESI‐MS, 1D and 2D NMR spectroscopic data analysis and comparison with literature data. Additionally, bioactivity study results showed that two new compounds have potential anti‐inflammatory activity. The plausible biosynthetic pathway for these compounds were also speculated in this article.     

New norlignans of Sequoiadendron gigantea; phytochemical comparison with Sequoia sempervirens

The permethyl ethers of three new norlignans (sequirins-E, -F, and -G) from Sequoiadendron gigantea heartwood have been characterized by NMR and MS as 2-(3,4-dimethoxyphenyl)-4-(4-methoxyphenyl-, 2,4-(3,4-dimethoxyphenyl)-, and 2-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-5-hydroxytetrahydropyran respectively, with the 2,5-trans,4,5-trans stereochemistry. Sequirins A-D, characteristic norlignans of Sequoia sempervirens Endl., could not be detected in S. gigantea heartwood, nor could sequirins E-G be found in S. sempervirens heartwood. Agatharesinol was a common constituent.     

中药五灵脂的化学成分研究

从中药五灵脂(Trogopterus xanthipes)的丙酮提取物中分离得到3个化合物,其结构经波谱鉴定为3-hy-droxy-(3-hydroxyphenyl)-benzenepropanol(1)、trans-2-(3,5-dihydroxybenzyl)-3-(3-hydroxybenzyl)-γ-butyrolactone(2)和tocopherylquinone(3)。其中化合物1为一个新的降木脂素类成分,化合物2为首次从自然界获得的新化合物,化合物3为首次从该中药中分离得到。化合物3在白血病肿瘤细胞株活性测定实验中显示中等的细胞毒活性,其IC50为20.7μM。