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Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis,randomized, double‐blind,placebo‐controlled trial
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Hamoun Anbari Amir Maghsoudi Mohammadreza Hosseinpour Fatemeh Yazdian 《Engineering in Life Science》2022,22(2):58
Curcumin is a polyphenolic molecule with antibacterial, antioxidant, anti‐inflammatory, and antimicrobial properties. This study aimed to prepare nanocurcumin by encapsulating in biopolymers to improve its stability, bioavailability, water‐solubility, antibacterial efficiency against methicillin‐resistant Staphylococcus aureus. Three effective variables of curcumin concentration, polymer concentration, and water volume on curcumin‐loaded polymer nanoparticles, were optimized. The average size of polyacrylic acid (PAA), polyvinyl alcohol (PVA), and polyethyleneimine (PEI) nanoparticles were obtained 75.2, 77.1, 86.4 nm, respectively. The nanoparticles had a spherical shape, a smooth and uniform surface morphology. The MIC of PAA, PVA, and PEI nanoparticles was 0.480, 0.390, and 0.340 mg/mL, respectively and the MIC of PAA, PVA, and PEI combined with methicillin was 0.330, 0.260, and 0.200 mg/mL, respectively. According to the results, curcumin‐loaded PEI nanoparticles had the highest inhibitory effect against methicillin‐resistant S. aureus among the synthesized nanoparticles. The results showed that solvent volume, polymer concentration and curcumin concentration had a significant effect on particle size. The inhibitory properties of curcumin nanoparticles significantly increased due to the smaller particle size and increased penetration into the bacterium. Curcumin‐loaded nanoparticles can be promising drug carriers for the treatment of infections, cancer, and other diseases. 相似文献
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Mehrzad Hajialilo Sanam Dolati Samaneh Abdolmohammadi-Vahid Majid Ahmadi Amin Kamrani Shadi Eghbal-Fard Arezou Ghassembaglou Amir Valizadeh Mohammad Hossein Musavi Shenas Leili Aghebati-Maleki Hossein Samadi Kafil Amir Mehdizadeh Mehdi Yousefi 《Journal of cellular biochemistry》2019,120(7):12027-12038
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