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Methylparaben induces malformations and alterations on apoptosis,oxidant–antioxidant status,ccnd1 and myca expressions in zebrafish embryos
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Perihan Seda Ateş İsmail Ünal Ünsal Veli Üstündağ Ahmet Ata Alturfan Türkan Yiğitbaşı Ebru Emekli‐Alturfan 《Journal of biochemical and molecular toxicology》2018,32(3)
Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure under sublethal doses are still unknown and the number of related studies is limited. Our aim was to evaluate the effects of MP on the development of zebrafish embryos focusing on development, locomotor activity, oxidant–antioxidant status, apoptosis, and ccnd1 and myca expressions. The expressions of ccnd1 and myca were determined by RT‐PCR. Lipid peroxidation (LPO), nitric oxide (NO), and glutathione‐S‐transferase (GST) activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Locomotor activity was measured using touch‐evoked movement test. MP exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group. Our findings will lead to further understanding of the mechanism of MP toxicity, and merit further research. 相似文献
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